Nitric Acid → HCID 86653799、化合物

反応式

[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][C:12](=[O:17])[C:13]([F:16])([F:15])[F:14])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[N+:18]([O-])([OH:20])=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]([N+:18]([O-:20])=[O:19])[C:5]([NH:11][C:12](=[O:17])[C:13]([F:15])([F:16])[F:14])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

参加物

反応物 2

HCID 944Nitric Acid

HCID 607598385-Fluoro-2-(2,2,2-trifluoroacetamido)benzoic acid

生成物 1

HCID 86653799HCID 86653799、化合物収率 80%

反応条件

温度: 0 °C

実験手順

5-Fluoro-2-(2,2,2-trifluoroacetamido) benzoic acid (140; 1.29 g, 5.1 mmol) was added, in small portions, to fuming nitric acid (7 mL) at 0° C. The resulting reaction mixture was stirred at 0° C. for 1 hand then poured into ice-water (10 mL). The resulting precipitate was collected by filtration, washed with water and dried to afford 5-fluoro-3-nitro-2-(2,2,2-trifluoroacetamido)benzoic acid 141 (1.2 g, 80%).

後処理

customThe resulting reaction mixture
filtrationThe resulting precipitate was collected by filtration
washwashed with water
customdried

出典と根拠

ORDレコード: ord-eb9115eb59cd499dbed7c841e89a44ea
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08846947B2

反応ノート

読み込み中…

参加物