Chloroacetone → HCID 11448585、化合物

HRID 851877ノート

反応式

HRID 851877 の反応式
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][S:9](=[O:11])(=[O:10])[C:5]=2[CH:4]=1.[H-].[Na+].Cl[CH2:18][C:19](=[O:21])[CH3:20]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[N:8]([CH2:18][C:19](=[O:21])[CH3:20])[S:9](=[O:11])(=[O:10])[C:5]=2[CH:4]=1

参加物

5

反応物 3

HCID 6571ChloroacetoneHCID 24758Sodium hydrideHCID 110747271,2-BENZISOTHIAZOL-3(2H)-ONE, 6-METHOXY, 1,1-DIOXIDE

生成物 1

HCID 11448585HCID 11448585、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

360 mg of 6-methoxy-1,1-dioxo-1,2-dihydro-benzo[d]isothiazol-3-one are added in small portions to a suspension of 72 mg of 60% NaH in mineral oil in 1.6 ml of anhydrous dimethylformamide. After stirring for 30 min. at ambient temperature, the reaction mixture becomes homogeneous and 162 μl of chloroacetone are added thereto. The reaction mixture is heated at 110° C. for 30 min. It is allowed to return to ambient temperature, and then the mixture is precipitated by addition of water. The precipitate is filtered off, rinsed several times with water, suction-filtered off and dried in vacuo.

後処理

  1. temperatureThe reaction mixture is heated at 110° C. for 30 min
  2. customto return to ambient temperature
  3. customthe mixture is precipitated by addition of water
  4. filtrationThe precipitate is filtered off
  5. washrinsed several times with water
  6. filtrationsuction-filtered off
  7. customdried in vacuo

出典と根拠

ORDレコード
ord-00a99096349849d78a777ca659d464d3
出典データセット
uspto-grants-2007_08
特許番号
US07253161B2

反応ノート

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