Hydrazine hydrate (1:1) → HCID 69414151、化合物

HRID 851891ノート

反応式

HRID 851891 の反応式
[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16](OC)=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1.O.[NH2:28][NH2:29]>CO.CN(C=O)C>[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16]([NH:28][NH2:29])=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 69414424HCID 69414424、化合物

生成物 1

HCID 69414151HCID 69414151、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6228Dimethylformamide溶媒

実験手順

A suspension of 500 mg (1.34 mmol) of the product obtained in Step A and 978 μl (20.13 mmol) of hydrazine monohydrate in a mixture of MeOH (30 ml) and DMF (6 ml) is refluxed for 24 hours. The MeOH is evaporated off, water is added to the reaction mixture and the precipitate, which corresponds to the title product, is filtered off.

後処理

  1. temperatureis refluxed for 24 hours
  2. customThe MeOH is evaporated off
  3. additionwater is added to the reaction mixture
  4. filtrationis filtered off

出典と根拠

ORDレコード
ord-862ff0c4f81b44cbb184e5c07dd910c3
出典データセット
uspto-grants-2007_08
特許番号
US07253163B2

反応ノート

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