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HRID 85190作成日：2026年10月26日

4-(Pyrrolidin-1-ylmethyl)aniline → 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide

https://huagongshe.com/reaction/85190

反応式

関与物質

役割名称HCID仕込み量
反応物4-(Pyrrolidin-1-ylmethyl)anilineHCID 776852—
反応物2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acidHCID 67202138—
生成物2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamideHCID 67201704—

反応手順

2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 159 was coupled with 4-(pyrrolidin-1-ylmethyl)aniline 160 to produce 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide (Compound 869) using the same general procedure outlined in Example 39. MS (ESI) calcd for C31H32F3N5O: 547.26; found: 548 [M+H].

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08846947B2
出典データセットuspto-grants-2014_09
ORD IDord-0539bb62776c46c1a37ae3165f4815f2
出典メモuspto-grants-2014_09