HRID85190

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID776852

未命名化合物

结构：O=C(O)c1cccc2[nH]c(-c3ccc(CN4CCCC4)cc3C(F)(F)F)nc12

HCID67202138

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(CN2CCCC2)cc1)c1cccc2[nH]c(-c3ccc(CN4CCCC4)cc3C(F)(F)F)nc12

HCID67201704

未命名化合物

PROCEDURE

实验过程

2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 159 was coupled with 4-(pyrrolidin-1-ylmethyl)aniline 160 to produce 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide (Compound 869) using the same general procedure outlined in Example 39. MS (ESI) calcd for C31H32F3N5O: 547.26; found: 548 [M+H].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0539bb62776c46c1a37ae3165f4815f2
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846947B2
来源说明: uspto-grants-2014_09

反应 SMILES

[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[NH:17][C:16]4[CH:18]=[CH:19][CH:20]=[C:21]([C:22]([OH:24])=O)[C:15]=4[N:14]=3)=[C:9]([C:25]([F:28])([F:27])[F:26])[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:29]1([CH2:34][C:35]2[CH:41]=[CH:40][C:38]([NH2:39])=[CH:37][CH:36]=2)[CH2:33][CH2:32][CH2:31][CH2:30]1>>[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[NH:17][C:16]4[CH:18]=[CH:19][CH:20]=[C:21]([C:22]([NH:39][C:38]5[CH:37]=[CH:36][C:35]([CH2:34][N:29]6[CH2:33][CH2:32][CH2:31][CH2:30]6)=[CH:41][CH:40]=5)=[O:24])[C:15]=4[N:14]=3)=[C:9]([C:25]([F:27])([F:26])[F:28])[CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1