Hydrochloric Acid → HCID 69198141、化合物

HRID 851904ノート

反応式

HRID 851904 の反応式
[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16]([O:18]C)=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1.Cl.[OH-:28].[Na+]>>[NH2:3][S:2]([C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][C:6]=1[N:5]1[CH2:23][CH2:24][CH2:25][C:4]1=[O:28])[O:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=1)[C:16]([OH:18])=[O:17])(=[O:26])=[O:1]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69414424HCID 69414424、化合物

生成物 1

HCID 69198141HCID 69198141、化合物

反応条件

温度
95 °C

実験手順

A suspension of the product obtained in Step A (1.1 g, 2.55 mmol) in 18 ml of 1N NaOH is heated at 95° C. until a solution is obtained. The solution is allowed to return to ambient temperature, is acidified with 1N HCl and extracted (CH2Cl2). The organic phases are combined, washed (saturated NaCl), dried (MgSO4) and evaporated. The residue is triturated in Et2O; the title product precipitates out and is recovered by filtration.

後処理

  1. customis obtained
  2. customto return to ambient temperature
  3. extractionextracted (CH2Cl2)
  4. washwashed (saturated NaCl)
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customThe residue is triturated in Et2O
  8. customthe title product precipitates out
  9. filtrationis recovered by filtration

出典と根拠

ORDレコード
ord-adc6694200354603bd574a2eea76fbad
出典データセット
uspto-grants-2007_08
特許番号
US07253162B2

反応ノート

読み込み中…