Hydrochloric Acid → 3-[(2,3-Dihydro-5,5-dioxido-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)-oxy]benzoic acid

HRID 851905ノート

反応式

HRID 851905 の反応式
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:18]=[CH:19][C:20]=1[N:21]1[CH2:25][CH2:24][CH2:23][C:22]1=O)[O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])(=[O:4])=[O:3].C1CCN2C(=NCCC2)CC1.Cl>C1COCC1>[O:3]=[S:2]1(=[O:4])[C:5]2[CH:6]=[C:7]([O:8][C:9]3[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=3)[C:12]([OH:14])=[O:13])[CH:18]=[CH:19][C:20]=2[N:21]2[CH2:25][CH2:24][CH2:23][C:22]2=[N:1]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 69198141HCID 69198141、化合物

生成物 1

HCID 691986953-[(2,3-Dihydro-5,5-dioxido-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)-oxy]benzoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A suspension of the product obtained in Step B (850 mg, 2.26 mmol) in 25 ml of THF in the presence of 675 μl (4.52 mmol) of DBU is refluxed for 1 hour. It is allowed to return to ambient temperature and is acidified with 1N HCl, and the white precipitate corresponding to the title product is filtered off. Elemental micro-analysis:

後処理

  1. temperatureis refluxed for 1 hour
  2. customto return to ambient temperature
  3. filtrationthe white precipitate corresponding to the title product is filtered off

出典と根拠

ORDレコード
ord-4f191a8288cb415482f2dee3eba0764a
出典データセット
uspto-grants-2007_08
特許番号
US07253162B2

反応ノート

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