1,1'-Carbonyldiimidazole → 4-Phenylbutyl perhydropyridazinecarboxylate

HRID 851940ノート

反応式

HRID 851940 の反応式
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[C:13]1([CH2:19][CH2:20][CH2:21][CH2:22][OH:23])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]1>C(Cl)Cl>[NH:24]1[CH2:29][CH2:28][CH2:27][CH:26]([C:1]([O:23][CH2:22][CH2:21][CH2:20][CH2:19][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:2])[NH:25]1

参加物

5

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 76889BenzenebutanolHCID 1363341,2-Diazinane

生成物 1

HCID 184700714-Phenylbutyl perhydropyridazinecarboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution containing 1,1′carbonyl diimidazole (0.893 g, 5.5 mmol) in 5 ml CH2Cl2 was added slowly to a solution of CH2Cl2 containing phenylbutyl alcohol (0.89 ml, 5.77 mmol). After stirring at room temperature for 1 hour, this solution was then added slowly to a solution containing perhydropyridazine mentioned above. The reaction was allowed to stir for overnight. The crude mixture was then concentrated and used without further purification.

後処理

  1. additionthis solution was then added slowly to a solution
  2. stirringto stir for overnight
  3. concentrationThe crude mixture was then concentrated
  4. customused without further purification

出典と根拠

ORDレコード
ord-a45f4825d1b644e09ccfb89885227551
出典データセット
uspto-grants-2007_08
特許番号
US07253169B2

反応ノート

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