3,3-Dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione → 3,3-Dimethyl-1-perhydropyridazinylpentane-1,2-dione

HRID 851945

反応式

HRID 851945 の反応式
[CH3:1][C:2]([CH3:22])([CH2:20][CH3:21])[C:3](=[O:19])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][N:7]1CC1C=CC=CC=1)=[O:5]>CCO.[Pd]>[CH3:1][C:2]([CH3:22])([CH2:20][CH3:21])[C:3](=[O:19])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][NH:7]1)=[O:5]

参加物

4

反応物 1

HCID 184700773,3-Dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione

生成物 1

HCID 694178043,3-Dimethyl-1-perhydropyridazinylpentane-1,2-dione

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1 g 10% Pd/C was added to a solution of 3,3-dimethyl-1-[2-benzylperhydropyridazinyl] pentane-1,2-dione (7.0 g, 20.2 mmol) in 70 ml EtOH. The mixture was under hydrogenation at room pressure (1 atm) overnight. The product was obtained as white solid after filtering Pd catalyst and concentration (3.8 g, 89%). 1H NMR (CDCl3, 400 MHz): δ 0.88 (t, 3H, J=7.0); 1.19 (s, 6H); 1.65 (m, 4H); 1.79 (m, 2H); 2.85 (m, 2H); 3.42 (m, 1H); 3.56 (m, 1H).

後処理

  1. customwas under hydrogenation at room pressure (1 atm) overnight
  2. customThe product was obtained as white solid
  3. filtrationafter filtering
  4. concentrationPd catalyst and concentration (3.8 g, 89%)

出典と根拠

ORDレコード
ord-9b7e691573c14d93926b276928e0a7b2
出典データセット
uspto-grants-2007_08
特許番号
US07253169B2

関連ノート

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