4,6-Dichloro-5-nitropyrimidine → (6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.Cl.[CH3:13][NH:14][CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17].CCN(C(C)C)C(C)C>CC(C)=O>[Cl:11][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:14]([CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:13])[C:7]=1[N+:8]([O-:10])=[O:9]参加物
5
実験手順
4,6-Dichloro-5-nitro-pyrimidine (0.20 g, 1.0 mmol), N-methyl-neopentylamine hydrochloride (0.14 g) and DIEA (0.2 mL) were stirred in acetone (5 mL) at 0° C. for 4 hours. The solvent was removed in vacuo and the crude product was used for the next reaction without purification.
後処理
- customThe solvent was removed in vacuo
- customthe crude product was used for the next reaction without purification
出典と根拠
- ORDレコード
- ord-f4886ded2a2d4c2fb1f4a159156b785e
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07253174B2
反応ノート
読み込み中…