(2-(Benzyloxy)pyridin-4-yl)methanol → 2-(Benzyloxy)isonicotinaldehyde

HRID 852068ノート

反応式

HRID 852068 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH:12]=[CH:11][N:10]=1)[CH:15]=[O:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 16096699(2-(Benzyloxy)pyridin-4-yl)methanol

生成物 1

HCID 229262712-(Benzyloxy)isonicotinaldehyde収率 89.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

A suspension of [2-(benzyloxy)-4-pyridyl]methanol (6.0 g) and activated manganese dioxide (30 g) in chloroform (180 mL) was heated under reflux for 2.5 hours. After the reaction solution was allowed to cool to room temperature, the manganese dioxide was filtered off and washed with ethyl acetate. The filtrate was concentrated to give the title compound as a pale brown oil (5.34 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours
  3. filtrationthe manganese dioxide was filtered off
  4. washwashed with ethyl acetate
  5. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-17676fa1028d4f38b483ccd90421ca33
出典データセット
uspto-grants-2007_08
特許番号
US07253178B2

反応ノート

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