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2-Chloro-alpha-(3-methoxyphenyl)-3-pyridinemethanol → (2-Chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-alpha-(3-methoxyphenyl)-3-pyridinemethanol | HCID 20145733 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (2-Chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone | HCID 10243711 | 66% |
反応手順
Combine (2-chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanol (9.40 g, 37.6 mmol), manganese (IV) oxide (30.0 g, 0.345 mol) and toluene (500 mL) and heat to reflux for one hour. Filter reaction mixture through celite, wash with toluene:dichloromethane mixture and evaporate to give the title compound (1.63 g, 66% Yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07253165B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-c911483f263244228b471f1f0eb54e62 |
| 出典メモ | uspto-grants-2007_08 |