Hydrochloric Acid → 2-Aminomethyl-3-(ethoxycarbonylmethoxy)pyridine dihydrochloride

HRID 852227ノート

反応式

HRID 852227 の反応式
[C:1]([C:3]1[C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].[ClH:16]>C(O)C.[Pd]>[ClH:16].[ClH:16].[NH2:2][CH2:1][C:3]1[C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 220385682-Cyano-3-(ethoxycarbonylmethoxy)pyridine

生成物 1

HCID 220385702-Aminomethyl-3-(ethoxycarbonylmethoxy)pyridine dihydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 2-cyano-3-(ethoxycarbonylmethoxy)pyridine (3.2 g, 15.52 mmol) in 180 ml of ethanol is added concentrated aqueous HCl (2.92 ml, 35 mmol) and 10% palladium on charcoal (1.5 g). After stirring for 4 hours under a hydrogen pressure of 4 bar, the mixture is filtered through celite, rinsed with ethanol and evaporated. The 2-aminomethyl-3-(ethoxycarbonylmethoxy)pyridine dihydrochloride thus obtained is sufficiently pure and used in the next step without further purification. Yield: 3.82 g (100%).

後処理

  1. filtrationthe mixture is filtered through celite
  2. washrinsed with ethanol
  3. customevaporated

出典と根拠

ORDレコード
ord-b3c206ab757744f4b608251217a4daf3
出典データセット
uspto-grants-2007_08
特許番号
US07253181B2

反応ノート

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