Sodium Iodide → Benzene, 1-(4-iodo-1-butyn-1-yl)-4-(trifluoromethyl)-

HRID 852359ノート

反応式

HRID 852359 の反応式
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][CH2:11][CH2:12]OS(C)(=O)=O)=[CH:5][CH:4]=1.[Na+].[I-:21]>CC(=O)CC>[I:21][CH2:12][CH2:11][C:10]#[C:9][C:6]1[CH:7]=[CH:8][C:3]([C:2]([F:19])([F:18])[F:1])=[CH:4][CH:5]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 86602536Methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester

生成物 1

HCID 69458210Benzene, 1-(4-iodo-1-butyn-1-yl)-4-(trifluoromethyl)-収率 98.8%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

反応条件

温度
90 °C

実験手順

To a solution of 3.16 g (10.81 mmol) methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester in 100 ml 2-butanone was added 3.24 g (21.62 mmol) NaI. The mixture was heated for 2 h at 90° C. The solvent was evaporated and the residue suspended in dichloromethane, ether was added and the suspension was filtrated. Evaporation of the organic phase gave 3.46 g of the title compound as an orange liquid.

後処理

  1. customThe solvent was evaporated
  2. additionether was added
  3. filtrationthe suspension was filtrated
  4. customEvaporation of the organic phase

出典と根拠

ORDレコード
ord-83e01209fab64aa5b919d9764167e053
出典データセット
uspto-grants-2007_08
特許番号
US07253192B2

反応ノート

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