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5-Chloro-2-(trifluoromethyl)pyrimidine → 2-Methyl-2-{2-methyl-4-[5-(2-trifluoromethyl-pyrimidin-5-yl)-pent-4-ynyloxy]-phenoxy}-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Chloro-2-(trifluoromethyl)pyrimidine | HCID 33697960 | — |
| 反応物 | HCID 86602542 | HCID 86602542 | — |
| 生成物 | 2-Methyl-2-{2-methyl-4-[5-(2-trifluoromethyl-pyrimidin-5-yl)-pent-4-ynyloxy]-phenoxy}-propionic acid | HCID 11531891 | — |
反応手順
In analogy to the procedure described in example 24E], 5-chloro-2-trifluoromethyl-pyrimidine (example 28B]) and 2-methyl-2-(2-methyl-4-pent-4-ynyloxy-phenoxy)-propionic acid (example 26B]), followed by flash chromatography (SiO2, CH2Cl2/MeOH 2.5 to 10%) and precipitation ether/n-pentane yielded the title compound as white powder, mp. 95-97° C., dec.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07253192B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-ef705838af9e43dd9761afc4bd26139e |
| 出典メモ | uspto-grants-2007_08 |