4-Oxo-6-phenyl-hex-5-enoic acid ethyl ester → 4-Oxo-6-phenylhexanoic acid
反応式
C([O:3][C:4](=[O:17])[CH2:5][CH2:6][C:7](=[O:16])[CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)C>C(O)C.[Pd]>[O:16]=[C:7]([CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH2:6][CH2:5][C:4]([OH:17])=[O:3]参加物
4
実験手順
A solution of 98 (5.0 g, 21 mmol) in ethanol (50 mL) was hydrogenated over 10% Pd—C at 30 psi and room temperature for 4 hr. The catalyst was filtered off and a soluton of NaOH (1 g) in water (10 mL) was added. The solution was stirred for 1 hr then diluted with water and washed with ether. The aqueous solution was acidified with HCl and extracted with ether. The ether extracts were washed with brine, dried over MgSO4 and evaporated to give an oil 4.1 g, 94%.
後処理
- filtrationThe catalyst was filtered off
- additiona soluton of NaOH (1 g) in water (10 mL) was added
- additionthen diluted with water
- washwashed with ether
- extractionextracted with ether
- washThe ether extracts were washed with brine
- dry with materialdried over MgSO4
- customevaporated
出典と根拠
- ORDレコード
- ord-a5f90e515e1d4af09d9026155f555b6c
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07253194B2
反応ノート
読み込み中…