Diethyl Ether → 4-Hydroxyimino-6-phenyl-hexanoic acid
反応式
O=[C:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].Cl.[NH2:17][OH:18].C[O-].[Na+].CCOCC>CO>[OH:18][N:17]=[C:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]参加物
6
実験手順
The ketone 99 (3.0 g, 13.6 mmol) and hydroxylamine hydrochloride (1.98 g, 27 mmol) were dissolved in methanol (20 mL) then sodium methoxide (2.9 g) was added. The solution was stirred and refluxed for 2 hr then cooled. Ether was added and the organic layer was washed twice with 2M HCl, brine and dried over MgSO4. Removal of solvent gave the oximes 100 (2.7 g 90%) as a mixture of E:Z isomers in the ratio 1.5:1.
後処理
- temperaturerefluxed for 2 hr
- temperaturethen cooled
- washthe organic layer was washed twice with 2M HCl, brine
- dry with materialdried over MgSO4
- customRemoval of solvent
出典と根拠
- ORDレコード
- ord-5353d4ad944d49e7bce5b3d97acdda7e
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07253194B2
反応ノート
読み込み中…