HCID 178477574、化合物 → HCID 178477570、化合物
反応式
C([N:8]([CH2:32][CH:33]1[CH2:35][CH2:34]1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([O:24][Si:25]([CH2:30][CH3:31])([CH2:28][CH3:29])[CH2:26][CH3:27])([C:20]([F:23])([F:22])[F:21])[C:16]([F:19])([F:18])[F:17])[CH2:11][CH2:10]1)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[CH:33]1([CH2:32][NH:8][C@H:9]2[CH2:10][CH2:11][C@H:12]([C:15]([O:24][Si:25]([CH2:28][CH3:29])([CH2:30][CH3:31])[CH2:26][CH3:27])([C:16]([F:17])([F:18])[F:19])[C:20]([F:23])([F:22])[F:21])[CH2:13][CH2:14]2)[CH2:34][CH2:35]1参加物
4
実験手順
1 g (ca 2.0 mmol) of crude trans benzyl-cyclopropylmethyl-[4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-cyclohexyl]-amine was dissolved in 50 mL of acetic acid, treated with 300 mg of Pd/C (10%) and hydrogenated overnight at atmospheric pressure under intense stirring. Filtration and evaporation of the solvent gave 775 mg (ca 82%) of crude trans cyclopropylmethyl-[4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-cyclohexyl]-amine as a yellow oil, MS: 434 (M+H)+.