Sodium Iodide → 1-Iodoethyl 2-acetoxybenzoate

HRID 85365

反応式

HRID 85365 の反応式
CC1[O:7][CH:6]([CH3:8])[O:5][CH:4]([CH3:9])O1.[Na+].[I-:11].[C:12]([O:15][C:16]1C=[CH:20][CH:19]=[CH:18][C:17]=1C(Cl)=O)(=[O:14])[CH3:13]>C(Cl)Cl>[C:12]([O:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:8]=1[C:6]([O:5][CH:4]([I:11])[CH3:9])=[O:7])(=[O:14])[CH3:13]

参加物

5

反応物 3

HCID 5238Sodium IodideHCID 31264ParaldehydeHCID 796682-Acetoxybenzoyl chloride

生成物 1

HCID 591932991-Iodoethyl 2-acetoxybenzoate収率 40%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a mixture of 2,4,6-trimethyl-1,3,5-trioxane (245 mg, 1.85 mmol) and NaI (0.972 g, 6.48 mmol) in DCM (15 mL) was added a solution of 2-(chlorocarbonyl)-phenyl acetate in DCM (5 mL, 0° C.). The resulting mixture was allowed to stir (RT, 16 h). The mixture was filtrated and concentrated under reduced pressure. The crude was purified by silica gel chromatography (EtOAc-PE, 0-10%) to afford 1-iodoethyl 2-acetoxybenzoate (0.75 g, 40%) as a light yellow oil.

後処理

  1. filtrationThe mixture was filtrated
  2. concentrationconcentrated under reduced pressure
  3. customThe crude was purified by silica gel chromatography (EtOAc-PE, 0-10%)

出典と根拠

ORDレコード
ord-72a7ffef402a44e3a4b4c7489ec3f10c
出典データセット
uspto-grants-2014_09
特許番号
US08846972B2

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