1-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one → 1-[2,5-Bis(2,2,2-trifluoroethoxy)phenyl]-3-[2,4-bis-(trifluoromethyl)phenyl]prop-2-en-1-one

HRID 853943

反応式

HRID 853943 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[F:22][C:23]([F:37])([F:36])[C:24]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:25]=1[CH:26]=O>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:26][C:25]1[CH:28]=[CH:29][C:30]([C:32]([F:35])([F:34])[F:33])=[CH:31][C:24]=1[C:23]([F:22])([F:36])[F:37]

参加物

3

反応物 2

HCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-oneHCID 27360952,4-Bis(trifluoromethyl)benzaldehyde

生成物 1

HCID 853377501-[2,5-Bis(2,2,2-trifluoroethoxy)phenyl]-3-[2,4-bis-(trifluoromethyl)phenyl]prop-2-en-1-one

実験手順

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 2,4-bis(trifluoromethyl)benzaldehyde (108 ul, 0.633 mmol) similar to Example 6 as a yellow solid (27 mg, 8%). 1H NMR (CDCl3): 8.03 (dd, J=2.0, 15.5 Hz, 1H), 7.97 (s, 1H), 7.93 (d, J=8.1 Hz, 1H), 7.86 (d, J=7.2 Hz, 1H), 7.50 (d, J=15.6 Hz, 1H), 7.35 (d, J=3.3 Hz, 1H), 7.18 (dd, J=3.3, 9.0 Hz, 1H), 6.95 (d, J=9.3 Hz, 1H), 4.47-4.35 (m, 4H).

出典と根拠

ORDレコード
ord-77de5c1a3622443784663dadef3b2457
出典データセット
uspto-grants-2007_08
特許番号
US07256219B2

関連ノート

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