Water → Pyridine-2-carboxylic acid [2-(4-nitro-phenyl)-3H-imidazo[4,5-c]pyridin-6-yl]-amide

HRID 854090

反応式

HRID 854090 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:19][C:13]3[CH:14]=[N:15][C:16]([NH2:18])=[CH:17][C:12]=3[N:11]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27](Cl)=[O:28].O>N1C=CC=CC=1>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:19][C:13]3[CH:14]=[N:15][C:16]([NH:18][C:27]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][N:21]=4)=[O:28])=[CH:17][C:12]=3[N:11]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 962WaterHCID 135033Picolinoyl Chloride HydrochlorideHCID 589329182-(4-Nitro-phenyl)-3H-imidazo[4,5-c]pyridine-6-ylamine

生成物 1

HCID 58932934Pyridine-2-carboxylic acid [2-(4-nitro-phenyl)-3H-imidazo[4,5-c]pyridin-6-yl]-amide収率 31.6%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of amine 8 (0.145 g, 0.57 mmol) and picolinoyl chloride hydrochloride (0.180 g, 1.01 mmol) in dry pyridine (5 ml) was stirred at room temperature overnight. After addition of water the brown solid was filtered and passed through a SiO2 gel, eluting with CH2Cl2: MeOH (100:5) affording the desired product 21 (0.065 g, 31%).

後処理

  1. filtrationwas filtered
  2. washeluting with CH2Cl2: MeOH (100:5)

出典と根拠

ORDレコード
ord-11d3075d86b149faa2357d917b9e7f11
出典データセット
uspto-grants-2007_08
特許番号
US07256287B2

関連ノート

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