Dimethylformamide → Thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl]ester

HRID 854305

反応式

HRID 854305 の反応式
Cl[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1.CN(C=O)C.[C:16]([O-:19])(=[S:18])[CH3:17].[K+]>O>[F:10][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][S:18][C:16](=[O:19])[CH3:17])=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 676221-(2-Chloroethyl)-4-fluorobenzeneHCID 23670855Potassium ethanethioate

生成物 1

HCID 23577239Thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl]ester

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2.4 g of 1-(2-chloro-ethyl)-4-fluoro-benzene, 30 mL of DMF, and 2.5 g of potassium thioacetate was stirred under nitrogen for 24 h. The mixture was diluted with 200 mL of water and extracted with 3×50 mL of dichloromethane. The combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. Drying under vacuum gave the product as an oil:

後処理

  1. extractionextracted with 3×50 mL of dichloromethane
  2. dry with materialThe combined organic layers were dried over magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customDrying under vacuum

出典と根拠

ORDレコード
ord-25effcfbf870484ba878e8e42f0a69ac
出典データセット
uspto-grants-2007_08
特許番号
US07259157B2

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