関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(Chloromethyl)-2-(4-methoxyphenyl)-1,3-thiazole | HCID 2517656 | — |
| 溶媒 | 2-Methyl-2-butanol | HCID 6405 | — |
| 生成物 | 1-[2-(4-Methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole | HCID 69428685 | 91% |
反応手順
A suspension of 2.40 g (10 mmol) 4-chloromethyl-2-(4-methoxy-phenyl)-thiazole, 1.02 g (15 mmol) imidazole, 0.17 g (1 mmol) potassium iodide and 0.60 g (15 mmol) sodium hydroxide in 25 ml 2-methyl-2-butanol was stirred at 120° C. for 5 h. After evaporation, the residue was quenched with water and extracted with ethyl acetate. The extract was dried and concentrated to yield 2.47 g (91%) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole as beige crystals, melting at 89-90° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07259262B2 |
|---|
| 出典データセット | uspto-grants-2007_08 |
|---|
| ORD ID | ord-3512ce16fd244329b6c1bd5a845dec70 |
|---|
| 出典メモ | uspto-grants-2007_08 |
|---|
