化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 4-[4-(Imidazol-1-ylmethyl)-thiazol-2-yl]-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 1-[2-(4-Methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole | HCID 69428685 | — |
| 溶媒 | Hydrogen Bromide | HCID 260 | — |
| 生成物 | 4-[4-(Imidazol-1-ylmethyl)-thiazol-2-yl]-phenol | HCID 136355233 | 85.5% |
反応手順
A solution of 0.54 g (2.0 mmol) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole in 15 ml 47% aqueous hydrobromic acid was stirred at 70° C. for 4 days. The reaction mixture was poured on ice, made basic with concentrated ammonia and extracted with ethyl acetate to yield 0.44 g (85%) raw 4-[4-(imidazol-1-ylmethyl)-thiazol-2-yl]-phenol as tan crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07259262B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-e53883339a67453d9791bc4ca221695e |
| 出典メモ | uspto-grants-2007_08 |