反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[C:10]([OH:12])=O)[CH:3]=[CH:2]1.[C:13]([C:17]1[CH:36]=[CH:35][C:20]([CH2:21][NH:22][CH2:23][CH2:24][N:25]([CH2:33][CH3:34])[C:26]2[CH:27]=[C:28]([CH3:32])[CH:29]=[CH:30][CH:31]=2)=[CH:19][CH:18]=1)([CH3:16])([CH3:15])[CH3:14].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[C:13]([C:17]1[CH:36]=[CH:35][C:20]([CH2:21][N:22]([CH2:23][CH2:24][N:25]([CH2:33][CH3:34])[C:26]2[CH:27]=[C:28]([CH3:32])[CH:29]=[CH:30][CH:31]=2)[C:10]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]3[C:9]=2[NH:1][CH:2]=[CH:3]3)=[O:12])=[CH:19][CH:18]=1)([CH3:15])([CH3:14])[CH3:16]参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
81 mg (0.50 mol) of 1H-indole-7-carboxylic acid, 162 mg (0.5 mmol) of N′-(4-tert-butyl-benzyl)-N-ethyl-N-m-tolyl-ethane-1,2-diamine and 108 mg (0.55 mmol) of EDC.HCl were dissolved in 5 ml DCM. The reaction mixture was stirred at rt over night. The solvent was evaporated and the residue was dissolved in diethyl ether. The organic layer was washed with 1N aqueous HCl solution, once with 1N aqueous NaOH solution and once with saturated aqueous NaCl solution, dried over sodium sulfate, filtered and the solvent was evaporated to leave 140 mg (55%) product as a colorless oil. MS (ISP) 468.4 (M+H)+.
後処理
- customThe solvent was evaporated
- dissolutionthe residue was dissolved in diethyl ether
- washThe organic layer was washed with 1N aqueous HCl solution, once with 1N aqueous NaOH solution and once with saturated aqueous NaCl solution
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-39ee5e229e144f9586dff008529c1e34
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07259183B2
関連ノート
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