Hydrazine hydrate (1:1) → HCID 11392773、化合物

HRID 855497ノート

反応式

HRID 855497 の反応式
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@H:11]2[C@H:15]([OH:16])[C@H:14]([OH:17])[C@@H:13]([CH2:18][OH:19])[O:12]2)=[C:4]([NH:20][CH3:21])[N:3]=1.O.[NH2:23][NH2:24]>>[NH:23]([C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@H:11]2[C@H:15]([OH:16])[C@H:14]([OH:17])[C@@H:13]([CH2:18][OH:19])[O:12]2)=[C:4]([NH:20][CH3:21])[N:3]=1)[NH2:24]

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 11243974(4S,2R,3R,5R)-2-[2-chloro-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

生成物 1

HCID 11392773HCID 11392773、化合物

実験手順

(4S,2R,3R,5R)-2-[2-chloro-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol, a compound of formula (2) (0.5 mmol), was suspended in hydrazine hydrate (5 mL), and the mixture was allowed to stir at room temperature for 24 hours. The hydrazine was removed under reduced pressure and the residue triturated with ether and filtered, to afford (4S,2R,3R,5R)-2-[2-hydrazino-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol, a compound of formula (3), as a white solid.

後処理

  1. customThe hydrazine was removed under reduced pressure
  2. customthe residue triturated with ether
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-2bd1735891764383a4d4279f4a45c891
出典データセット
uspto-grants-2007_08
特許番号
US07262176B2

反応ノート

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