Nitric Acid → N-(4-Methoxy-2-methyl-5-nitrophenyl)acetamide

HRID 855793

反応式

HRID 855793 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([CH3:13])[CH:4]=1.[N+:14]([O-])([OH:16])=[O:15]>C(O)(=O)C>[CH3:1][O:2][C:3]1[C:8]([N+:14]([O-:16])=[O:15])=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([CH3:13])[CH:4]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 95082N-(4-Methoxy-2-methylphenyl)-acetamide

生成物 1

HCID 21260362N-(4-Methoxy-2-methyl-5-nitrophenyl)acetamide収率 53%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

34 g(0.19 mol) of N-(4-methoxy-2-methylphenyl)acetamide were added in small portions to a mixture of 40 ml of glacial acetic acid and 70 ml of fuming nitric acid at −10 to −15° C. These portions were such that the temperature did not rise above −10° C. The reaction mixture was then poured onto ice. The resulting precipitate was filtered off with suction and washed with water, ethanol and diethyl ether. 22.5 g (53%) of the desired product were obtained.

後処理

  1. customdid not rise above −10° C
  2. additionThe reaction mixture was then poured onto ice
  3. filtrationThe resulting precipitate was filtered off with suction
  4. washwashed with water, ethanol and diethyl ether

出典と根拠

ORDレコード
ord-a9382db83abc43b581f2ceecf610637b
出典データセット
uspto-grants-2007_08
特許番号
US07262220B2

関連ノート

読み込み中…