Methanol → L-Tryptophan

HRID 855898

反応式

HRID 855898 の反応式
[CH2:1]([N:11]=[C:12]=S)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]C.[CH3:14][OH:15].[OH2:16].C[N:18](C=O)C>>[NH2:18][C@H:9]([C:14]([OH:16])=[O:15])[CH2:8][C:7]1[C:6]2[C:1](=[CH:2][CH:3]=[CH:4][CH:5]=2)[NH:11][CH:12]=1

参加物

5

反応物 4

HCID 887MethanolHCID 962WaterHCID 6228DimethylformamideHCID 90535Decane, 1-isothiocyanato-

生成物 1

HCID 6305L-Tryptophan

実験手順

To a suspension of compound AA (9.1 g) in dry N,N′-dimethylformamide (15 ml) was added n-decylisothiocyanate (1.2 ml). The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was poured on to Bondesil 40 μM C8 resin (400 g) that had been prewashed with methanol (1 L) and water (1 L). The product was eluted with methanol (800 ml) after being first washed with water (800 ml) followed by 20% acetonitrile in water (800 ml). Evaporation of the methanol gave compound BB as a yellow solid (7.3 g).

後処理

  1. washThe product was eluted with methanol (800 ml)
  2. washafter being first washed with water (800 ml)
  3. customEvaporation of the methanol

出典と根拠

ORDレコード
ord-bc301b1918944d069b746bb6779c014c
出典データセット
uspto-grants-2007_08
特許番号
US07262268B2

関連ノート

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