Dichloromethane → 4-(4-Trifluoromethylphenylamino)piperidine-1-carbonylchloride
反応式
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([NH:9]N2CCCCC2)=[CH:5][CH:4]=1.[Cl:18][C:19](Cl)([O:21]C(=O)OC(Cl)(Cl)Cl)Cl.C([N:32]([CH2:35][CH3:36])[CH2:33][CH3:34])C.[CH2:37](Cl)Cl>>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[CH:5][C:6]([NH:9][CH:37]2[CH2:34][CH2:33][N:32]([C:19]([Cl:18])=[O:21])[CH2:35][CH2:36]2)=[CH:7][CH:8]=1参加物
5
実験手順
A mixture of (4-trifluoromethylphenylamino)-piperidine (1.14 g, 4.67 mmol), triphosgene (0.55 g, 1.87 mmol), and triethylamine (0.98 ml, 7.01 mmol) in methylene chloride (10 ml) was stirred at room temperature for 1.5 hours. The reaction mixture was washed with water, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford 4-(4-trifluoromethylphenylamino)piperidine-1-carbonylchloride (1.43 g, quantitative) as a pale yellow oil.
後処理
- washThe reaction mixture was washed with water
- dry with materialdried over magnesium sulfate
- filtrationAfter filtration
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-294c295f681641c0bb6a5b434c65f72b
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07262212B2
反応ノート
読み込み中…