Thionyl Chloride → HCID 22938786、化合物

HRID 856644ノート

反応式

HRID 856644 の反応式
[CH2:1]([N:3]1[CH:7]=[N:6][N:5]=[C:4]1[CH2:8]O)[CH3:2].S(Cl)([Cl:12])=O>>[ClH:12].[Cl:12][CH2:8][C:4]1[N:3]([CH2:1][CH3:2])[CH:7]=[N:6][N:5]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 22938611(4-ethyl-4H-1,2,4-triazol-3-yl)methanol

生成物 1

HCID 22938786HCID 22938786、化合物

実験手順

To 4-ethyl-3-hydroxymethyl-4H-1,2,4-triazole (4.6 g), thionyl chloride (36 ml) was slowly added at 0° C. The mixture was heated to reflux for 1 hour, and concentrated under reduced pressure. To the residue was added ethyl acetate and ethanol, and the precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate, to give 3-chloromethyl-4-ethyl-4H-1,2,4-triazole hydrochloride (4.22 g) as orange crystals.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hour
  3. concentrationconcentrated under reduced pressure
  4. additionTo the residue was added ethyl acetate and ethanol
  5. filtrationthe precipitated crystals were collected by filtration
  6. washThe crystals were washed with ethyl acetate

出典と根拠

ORDレコード
ord-72fe571441664a4e9be409866d900805
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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