Sodium Hydroxide → N-methyl-1-(4-nitrophenyl)methanamine

HRID 856658

反応式

HRID 856658 の反応式
[CH3:1][N:2]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1)C(=O)C(F)(F)F.[OH-].[Na+]>CO>[CH3:1][NH:2][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 21953032N-methyl-N-(4-nitrobenzyl)trifluoroacetoamide

生成物 1

HCID 409440N-methyl-1-(4-nitrophenyl)methanamine収率 90.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-methyl-N-(4-nitrobenzyl)trifluoroacetoamide (11.82 g) in methanol (200 ml) was added 1N aqueous solution of sodium hydroxide (50 ml) at room temperature. The mixture was stirred at room temperature for 24 hours, and concentrated under reduced pressure. The mixture was extracted with ethyl acetate and dried over magnesium sulfate. The mixture was concentrated under reduced pressure, to give methyl(4-nitrobenzyl)amine (6.78 g).

後処理

  1. concentrationconcentrated under reduced pressure
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-28bdd760140a41e99235eed51e855ef0
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

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