Thionyl Chloride → 2-Chloromethyl-1-propylimidazole hydrochloride
反応式
O[CH2:2][C:3]1[N:4]([CH2:8][CH2:9][CH3:10])[CH:5]=[CH:6][N:7]=1.S(Cl)([Cl:13])=O>>[ClH:13].[Cl:13][CH2:2][C:3]1[N:4]([CH2:8][CH2:9][CH3:10])[CH:5]=[CH:6][N:7]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
To 2-hydroxymethyl-1-propylimidazole (8.0 g) was added thionyl chloride (50 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure, and the obtained residue was recrystallized from methanol-ethyl acetate, to give 2-chloromethyl-1-propylimidazole hydrochloride (4.3 g) as yellow crystals.
後処理
- customto be at room temperature
- distillationThe solvent was distilled off under reduced pressure
- customthe obtained residue was recrystallized from methanol-ethyl acetate
出典と根拠
- ORDレコード
- ord-06c3e0b73d594c86b1f4ba5aa1414ce9
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07262185B2
反応ノート
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