Thionyl Chloride → HCID 22938853、化合物

HRID 856756ノート

反応式

HRID 856756 の反応式
[CH:1]1([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[C:6]2[CH2:10]O)[CH2:3][CH2:2]1.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:10][C:6]1[N:5]([CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH:9]=[CH:8][N:7]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 229387391-Cyclopropylmethyl-2-hydroxymethylimidazole

生成物 1

HCID 22938853HCID 22938853、化合物

反応条件

温度
90 °C

実験手順

To 1-cyclopropylmethyl-2-hydroxymethylimidazole (2.50 g) was added thionyl chloride (25 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature, the solvent was distilled off under reduced pressure and the obtained solid was washed with ethyl acetate, to give 2-chloromethyl-1-cyclopropylmethylimidazole hydrochloride. (2.96 g) as brown crystals.

後処理

  1. customto be at room temperature
  2. distillationthe solvent was distilled off under reduced pressure
  3. washthe obtained solid was washed with ethyl acetate

出典と根拠

ORDレコード
ord-813269d41bda4f7791b86ff74507be63
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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