Thionyl Chloride → 5-Chloromethyl-4-methyl-1-propylimidazole hydrochloride
反応式
O[CH2:2][C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[CH:6]=[N:5][C:4]=1[CH3:11].S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:2][C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[CH:6]=[N:5][C:4]=1[CH3:11]参加物
3
反応条件
- 温度
- 90 °C
実験手順
To 5-hydroxymethyl-4-methyl-1-propylimidazole (2.4 g) was added thionyl chloride (10 ml) at 0° C., and the mixture was heated for 30 minutes at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was dissolved in methanol. The solvent was distilled off again under reduced pressure, to give 5-chloromethyl-4-methyl-1-propylimidazole hydrochloride (3.13 g) as brown oil.
後処理
- customto be at room temperature
- distillationThe solvent was distilled off under reduced pressure
- dissolutionthe obtained residue was dissolved in methanol
- distillationThe solvent was distilled off again under reduced pressure
出典と根拠
- ORDレコード
- ord-3112afcb917c407aa31fbe834092ed52
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07262185B2
反応ノート
読み込み中…