Thionyl Chloride → 3-(Chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine hydrochloride

HRID 856787ノート

反応式

HRID 856787 の反応式
[N:1]1[CH:2]=[C:3]([CH2:10]O)[N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=12.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:10][C:3]1[N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]2=[N:1][CH:2]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 229385385,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-3-ylmethanol

生成物 1

HCID 229385113-(Chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine hydrochloride

実験手順

To 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-3-yl methanol (1.0 g), thionyl chloride (5 ml) was added at 0° C. After heating to reflux for 40 minutes, the mixture was concentrated under reduced pressure. To the residue was added ethyl acetate, and the precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate, to give 3-(chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine hydrochloride (1.03 g) as pale yellow crystals.

後処理

  1. temperatureAfter heating
  2. temperatureto reflux for 40 minutes
  3. concentrationthe mixture was concentrated under reduced pressure
  4. additionTo the residue was added ethyl acetate
  5. filtrationthe precipitated crystals were collected by filtration
  6. washThe crystals were washed with ethyl acetate

出典と根拠

ORDレコード
ord-5a113966d87b4507ad2682dc12a781c3
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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