Water → 2-(2-Chlorophenyl)cyclopropanecarboxylic acid

HRID 857003

反応式

HRID 857003 の反応式
CON(C)[C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:5].[OH2:17].[OH-].[Na+]>CO>[Cl:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH:7]1[CH2:8][CH:6]1[C:4]([OH:17])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 587594752-(2-Chlorophenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide

生成物 1

HCID 218646682-(2-Chlorophenyl)cyclopropanecarboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-(2-chloro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide (9.6 g), water (20 mL), and NaOH (3.2 g) in MeOH (40 mL) was refluxed for 3 h. The reaction mixture was cooled down to room temperature and concentrated in vacuo. The residue was acidified by 6 N HCl followed by extraction with CH2Cl2. The organic layer was washed with brine, dried over MgSO4 and concentrated in vacuo to give the title compound (7.8 g).

後処理

  1. temperaturewas refluxed for 3 h
  2. concentrationconcentrated in vacuo
  3. extractionfollowed by extraction with CH2Cl2
  4. washThe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-98b7c5c04e7d4f3da71310343e4146fa
出典データセット
uspto-grants-2006_12
特許番号
US07144881B2

関連ノート

読み込み中…