Water → 2-(2,5-Difluorophenyl)cyclopropane-1-carboxylic acid

HRID 857018ノート

反応式

HRID 857018 の反応式
CON(C)[C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[F:16])=[O:5].[OH2:18].[OH-].[Na+]>CO>[F:16][C:10]1[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:9]=1[CH:7]1[CH2:8][CH:6]1[C:4]([OH:18])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 587594682-(2,5Difluoro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide

生成物 1

HCID 218646562-(2,5-Difluorophenyl)cyclopropane-1-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-(2,5-difluoro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide (9.6 g), water (20 mL), and NaOH (3.2 g) in MeOH (40 mL) was refluxed for 3 h. The reaction mixture was cooled down to room temperature and concentrated in vacuo. The residue was acidified by 6 N HCl followed by extraction with CH2Cl2. The organic layer was washed with brine, dried over MgSO4 and concentrated in vacuo to give the title compound (7.8 g).

後処理

  1. temperaturewas refluxed for 3 h
  2. concentrationconcentrated in vacuo
  3. extractionfollowed by extraction with CH2Cl2
  4. washThe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-6641a8c6dfa44a82a822587065683740
出典データセット
uspto-grants-2006_12
特許番号
US07144881B2

反応ノート

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