Water → N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide

HRID 857068

反応式

HRID 857068 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[C:17]1([CH3:27])[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1.O>N1C=CC=CC=1>[S:9]1[C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[N:12]=[C:8]1[C:5]1[CH:4]=[CH:3][C:2]([NH:1][S:23]([C:20]2[CH:21]=[CH:22][C:17]([CH3:27])=[CH:18][CH:19]=2)(=[O:25])=[O:24])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 2344752-(4-Aminophenyl)benzothiazole

生成物 1

HCID 4380499N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒2 回

実験手順

To 2-(4-aminophenyl)benzothiazole (0.5 g, 2.2 mmol) in pyridine (6 mL) is added para-toluenesulphonyl chloride (0.506 g, 2.7 mmol, 1.5 eq.) in pyridine (4 mL). The reaction mixture is heated at reflux for 10 mins, then cooled and water (10 mL) added. The white precipitate formed is collected on a filter, washed with water, and dried under vacuum to give N-[4-(benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide as a white solid.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 10 mins
  3. temperaturecooled
  4. customThe white precipitate formed
  5. customis collected on a filter
  6. washwashed with water
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-8126ba76e63641bbac8c1bf34ce2e323
出典データセット
uspto-grants-2006_12
特許番号
US07144893B2

関連ノート

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