Water → N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide

HRID 857072

反応式

HRID 857072 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[C:17]1([CH3:27])[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1.O>N1C=CC=CC=1>[S:9]1[C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[N:12]=[C:8]1[C:5]1[CH:4]=[CH:3][C:2]([NH:1][S:23]([C:20]2[CH:21]=[CH:22][C:17]([CH3:27])=[CH:18][CH:19]=2)(=[O:25])=[O:24])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 2344752-(4-Aminophenyl)benzothiazole

生成物 1

HCID 4380499N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒2 回

実験手順

To 2-(4-aminophenyl)-benzothiazole (0.5 g, 2.2 mmol) in pyridine (6 mL) was added para-toluenesulphonyl chloride (0.506 g, 2.7 mmol, 1.5 equiv.) in pyridine (4 mL). The reaction mixture was heated at reflux for 10 mins, then cooled and water (10 mL) added. The white precipitate formed was collected on a filter, washed with water and dried under vacuum to give N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide as a white solid. The yield was 0.807 g (96%).

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 10 mins
  3. temperaturecooled
  4. customThe white precipitate formed
  5. customwas collected on a filter
  6. washwashed with water
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-72529ed308ac452380d4c4070f272ff0
出典データセット
uspto-grants-2006_12
特許番号
US07144893B2

関連ノート

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