1,3-Dichloroacetone → (4-Chloromethyl-thiazol-2-yl)-naphthalen-1-yl-amine

HRID 857080ノート

反応式

HRID 857080 の反応式
[C:1]1([NH:11][C:12]([NH2:14])=[S:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:15][CH2:16][C:17]([CH2:19]Cl)=O>CC(C)=O>[Cl:15][CH2:16][C:17]1[N:14]=[C:12]([NH:11][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)[S:13][CH:19]=1

参加物

4

反応物 2

HCID 107931,3-DichloroacetoneHCID 736366Alpha-Naphthylthiourea

生成物 1

HCID 21866567(4-Chloromethyl-thiazol-2-yl)-naphthalen-1-yl-amine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of naphthalen-1-yl-thiourea (iii) (2.02 g, 10 mmol) in acetone (50 mL) at room temperature was added 1,3-dichloroacetone (1.03 g, 10.5 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was filtered and washed with methanol. The filtrate was treated with hexane to afford a white precipitate. The precipitate was filtered and washed with hexane.

後処理

  1. filtrationThe reaction mixture was filtered
  2. washwashed with methanol
  3. additionThe filtrate was treated with hexane
  4. customto afford a white precipitate
  5. filtrationThe precipitate was filtered
  6. washwashed with hexane

出典と根拠

ORDレコード
ord-01f4098aa1b34fafbb1a2eada84a92d2
出典データセット
uspto-grants-2006_12
特許番号
US07144903B2

反応ノート

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