Hydrochloric Acid → 3-(3-Iodophenyl)imidazolidine-2,4-dione
反応式
[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH:11][CH2:12][C:13]([O:15]CC)=O)=[O:10])[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].Cl>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[O:15])[CH2:12][NH:11][C:9]2=[O:10])[CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
A solution of ethyl N-{[(3-iodophenyl)amino]carbonyl}glycinate (9.42 g) in DMF (60 ml) was treated with sodium hydride (60% oil dispersion, 1.2 g) at 20° C. After 2 h the reaction mixture was treated with aqueous 2M HCl (200 ml) and stirred overnight. The solid was collected by filtration, washed with water and dried to give the title compound (6.9 g) LCMS RT=2.45 min.
後処理
- filtrationThe solid was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-64023520ea564a86a19be31abc8c1cae
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07144908B2
反応ノート
読み込み中…