Ethanol → Ethyl 2-{[(3-iodophenyl)amino]carbonyl}hydrazinecarboxylate
反応式
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[NH:2][NH2:3].[I:8][C:9]1[CH:10]=[C:11]([N:15]=[C:16]=[O:17])[CH:12]=[CH:13][CH:14]=1.C(O)C>ClCCl>[I:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH:3][NH:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:17])[CH:12]=[CH:13][CH:14]=1参加物
5
反応条件
- 温度
- 20 °C
実験手順
A solution of ethyl carbazate (1.25 g) in dichloromethane (20 ml) was treated with 3-iodophenylisocyanate (1.7 g) at 0° C. The reaction mixture was allowed to warm to 20° C. and stirred for 2 h. Ethanol (2 ml) was added and the mixture was stirred for 0.5 h. The solvents were removed under reduced pressure and the residue was triturated in diethyl ether. The white solid was collected by filtration to give the title compound (2.4 g). LCMS RT=2.81 min
後処理
- stirringthe mixture was stirred for 0.5 h
- customThe solvents were removed under reduced pressure
- customthe residue was triturated in diethyl ether
- filtrationThe white solid was collected by filtration
出典と根拠
- ORDレコード
- ord-e603dd6d9b484b44a170870b3bcfc6ce
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07144908B2
反応ノート
読み込み中…