Hydrochloric Acid → 4-(Methanesulfonyl)piperidine
反応式
[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].Cl>C1COCC1>[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3]参加物
4
反応条件
- 温度
- 20 °C
実験手順
A mixture of tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate (1.5 g, 5.70 mmol) and hydrogen chloride (7.12 mL, 28.5 mmol) in THF (20 mL) was stirred at 20° C. for 15 hours. TLC indicated the formation of desired product, the reaction mixture was filtered and the pale yellow solid was collected to provide desired product (1 g, 88%). LCMS: m/e 163.96 (M+H)+, 0.25 min (method 10).
出典と根拠
- ORDレコード
- ord-fe60ead0482c4a67a8aa2f5848de269c
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846647B2
反応ノート
読み込み中…