Nitromethane → 5-Nitro-2-pentanone

HRID 857441ノート

反応式

HRID 857441 の反応式
[CH:1]([C:3]([CH3:5])=[O:4])=[CH2:2].[N+:6]([CH3:9])([O-:8])=[O:7].[F-].[K+]>C1COCC1>[N+:6]([CH2:9][CH2:2][CH2:1][C:3](=[O:4])[CH3:5])([O-:8])=[O:7]

参加物

5

反応物 3

HCID 6375NitromethaneHCID 6570Methyl vinyl ketoneHCID 522689Potassium Fluoride

生成物 1

HCID 42950035-Nitro-2-pentanone収率 93.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl vinyl ketone (4.17 ml, 0.05 moles), nitromethane (24.4 ml, 0.45 moles) and THF (250 ml) were mixed and stirred together under nitrogen. Potassium fluoride on alumina (10 g) was added and the mixture stirred for 2 hours at ambient temperature. The reaction was filtered and the filtrate was evaporated to give crude 5-nitro-2-pentanone as a pale yellow oil (6.11 g, 93%).

後処理

  1. stirringthe mixture stirred for 2 hours at ambient temperature
  2. filtrationThe reaction was filtered
  3. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-4850c597e41e47429cd877545da0ffbf
出典データセット
uspto-grants-2006_12
特許番号
US07145014B2

反応ノート

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