2-(1H-1,2,4-triazol-1-yl)Benzonitrile → [2-(1H-1,2,4-triazol-1-yl)phenyl]methanamine

HRID 857723ノート

反応式

HRID 857723 の反応式
[N:1]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]#[N:13])[CH:5]=[N:4][CH:3]=[N:2]1>[Pd].C(O)C>[N:1]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:12][NH2:13])[CH:5]=[N:4][CH:3]=[N:2]1

参加物

4

反応物 1

HCID 157121632-(1H-1,2,4-triazol-1-yl)Benzonitrile

生成物 1

HCID 4913133[2-(1H-1,2,4-triazol-1-yl)phenyl]methanamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-(1,2,4-triazol-1-yl)cyanobenzene (508 mg, 2.99 mmol) and 25% by weight of palladium on carbon, 10% catalyst (134 mg) in ethanol (75 ml) was placed on a PARR Hydrogenation Apparatus under a hydrogen atmosphere at 55 psi. overnight. The mixture was filtered through celite and concentrated to give 2-(1,2,4-triazol-1-yl)-benzylamine; 1H NMR (CD3OD) δ 8.80 (s, 1H), 8.22 (s, 1H), 7.64–7.43 (m, 4H), 3.66 (s, 2H).

後処理

  1. customovernight
  2. filtrationThe mixture was filtered through celite and
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-dd4bb516616741e38e51dc33ec9995ef
出典データセット
uspto-grants-2006_12
特許番号
US07144899B2

反応ノート

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