Methanol → Methyl D-arabinofuranoside
反応式
[O:1]=[CH:2][C@H:3]([C@@H:5]([C@@H:7]([CH2:9][OH:10])[OH:8])[OH:6])[OH:4].[CH3:11]O>Cl>[O:1]([CH3:11])[CH:2]1[O:8][C@H:7]([CH2:9][OH:10])[C@@H:5]([OH:6])[C@@H:3]1[OH:4]参加物
4
実験手順
D-Arabinose (1, 25 g, 167 mmol) was stirred for 5 hours in 0.5% hydrogen chloride in methanol (675 mL) at room temperature and then neutralized with Amberlite IRA-400 OH anion exchange resin. The filtrate and washings were combined and evaporated to dryness and the crude product was purified by silica gel chromatography (CHCl3/MeOH, 92:8) to afford 26.2 g of methyl D-arabinofuranoside (2, 95% yield) as an and (1:1) mixture. MS 164 (M)+.
後処理
- customevaporated to dryness
- customthe crude product was purified by silica gel chromatography (CHCl3/MeOH, 92:8)
出典と根拠
- ORDレコード
- ord-7e666b16ceb8413fb376c4980a514b8d
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07148223B2
反応ノート
読み込み中…