Hydrochloric Acid → HCID 178473974、化合物

HRID 858298

反応式

HRID 858298 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].[N:14]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[C:20](O)=[O:21].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)C(C)C)C.Cl>CN(C=O)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:20]([OH:21])[C:15]2[CH:16]=[N:17][CH:18]=[CH:19][N:14]=2)[C:5]1=[O:13])(=[O:3])[CH3:2]

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 10472-Pyrazinecarboxylic acidHCID 81531DiisopropylethylamineHCID 3237191-Acetylindolin-2-oneHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

生成物 1

HCID 178473974HCID 178473974、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4.38 g 1-acetyl-2-indolinone, 3.41 g pyrazine-2-carboxylic acid, 8.83 g TBTU, 4.21 g HOBT-hydrate and 21.8 ml ethyldiisopropylamine are stirred in 70 ml DMF for 15 hours at ambient temperature. The mixture is poured onto 400 ml ice water and 10 ml of conc. hydrochloric acid and stirred for 1 hour. The precipitate is suction filtered, washed with water, stirred with methanol, suction filtered again, washed with methanol and dried at 100° C.

後処理

  1. filtrationfiltered
  2. washwashed with water
  3. stirringstirred with methanol, suction
  4. filtrationfiltered again
  5. washwashed with methanol
  6. customdried at 100° C.

出典と根拠

ORDレコード
ord-7a56fe76223341628f39ab52bed4f6ba
出典データセット
uspto-grants-2006_12
特許番号
US07148249B2

関連ノート

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