Benzyl ethyl 2-(6-nitro-3-pyridinyl)malonate → Ethyl 2-(6-nitropyridin-3-yl)acetate

HRID 858511ノート

反応式

HRID 858511 の反応式
[N+:1]([C:4]1[N:9]=[CH:8][C:7]([CH:10](C(OCC)=O)[C:11]([O:13][CH2:14][C:15]2C=CC=CC=2)=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2]>C(O)C.[Pd]>[N+:1]([C:4]1[N:9]=[CH:8][C:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 1

HCID 21875897Benzyl ethyl 2-(6-nitro-3-pyridinyl)malonate

生成物 1

HCID 21300451Ethyl 2-(6-nitropyridin-3-yl)acetate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of benzyl ethyl 2-(6-nitro-3-pyridinyl)malonate (5.26 g, 15.3 mmol,) in ethanol was added palladium on carbon (530 mg) and stirred for 6 h under hydrogen atmosphere at room temperature. The catalyst was filtered off through a pad of celite and the filtrate was concentrated to give a title compound as yellow brown oil.

後処理

  1. filtrationThe catalyst was filtered off through a pad of celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-a0fea634948f49f082b00fa8489a255b
出典データセット
uspto-grants-2006_12
特許番号
US07148234B2

反応ノート

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