Sodium Hydroxide → 2-Oxo-1-pyrrolidinepropanoic acid
反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7]CC#N.[OH-:11].[Na+].[O:13]1[CH2:18][CH2:17]OCC1>>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:17][C:18]([OH:13])=[O:11]参加物
4
実験手順
A solution of 2-oxo-1-pyrrolidinepropionitrile (22.4 g, 16.2 mmol), 15% NaOH solution (40 mL) and dioxane (40 mL) was heated under reflux for 5 h under N2. The reaction mixture was extracted with EtOAc. The aqueous layer was made acidic with 6N HCl amd extracted with CH2Cl2 (5×50 mL). The organic layers were dried over Na2SO4 and concentrated to give the title compound as a cream solid (12.4 g, 49%).
後処理
- temperatureunder reflux for 5 h under N2
- extractionThe reaction mixture was extracted with EtOAc
- extractionamd extracted with CH2Cl2 (5×50 mL)
- dry with materialThe organic layers were dried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c32affedab5246dd8e5a9d2751af7cf3
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07148226B2
反応ノート
読み込み中…