HCID 58762226、化合物 → 1-(4-Methoxyphenyl)pentan-3-one
反応式
[CH2:1]([Mg]Br)[CH3:2].CON(C)[C:8](=[O:19])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1>C1COCC1>[CH3:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][C:8](=[O:19])[CH2:1][CH3:2])=[CH:12][CH:13]=1参加物
4
実験手順
Ethylmagnesium bromide (10.8 mL, 10.8 mmol, 1M soln in THF) was added to a cooled −78° C. solution of N-Methoxy-3-(4-methoxy-phenyl)-N-methyl-propionamide (2 g, 8.96 mmol, from Step 1) dissolved in THF (20 mL). The reaction mixture was stirred for 60 min. The reaction was quenched with saturated NH4Cl and extracted with EtOAc. The organic layer was washed brine, dried over Na2SO4 and concentrated to a clear oil. The residue was purified by silica gel chromatography (5% EtOAc in hexanes) to give the title compound as a clear oil (0.87 g, 50%).
後処理
- customThe reaction was quenched with saturated NH4Cl
- extractionextracted with EtOAc
- washThe organic layer was washed brine
- dry with materialdried over Na2SO4
- concentrationconcentrated to a clear oil
- customThe residue was purified by silica gel chromatography (5% EtOAc in hexanes)
出典と根拠
- ORDレコード
- ord-7fc014611fc5415ab452a71bfad19d57
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07148226B2
反応ノート
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